منابع مشابه
How is genome sequencing done
Step One – DNA sample preparation; Step Two – Proprietary process to load DNA sample onto beads; Step Three – Sequencing DNA on Genome Sequencer FLX instrument; and Step Four –Analysis of the genome
متن کاملHow is genome sequencing done
Step One – DNA sample preparation; Step Two – Proprietary process to load DNA sample onto beads; Step Three – Sequencing DNA on Genome Sequencer FLX instrument; and Step Four –Analysis of the genome
متن کاملidentification and discovery of novel micrornas in the human genome
although more than 98% of the human genome is transcribed, most of these transcripts are not translated into proteins. rather, they are considered as non-coding rnas. micrornas (mirnas) are very short non-coding rnas approximately 22 nucleotides in length which regulate many key processes of cells such as growth, proliferation, differentiation, cell cycle, apoptosis (programmed cell death) and ...
متن کاملDeep whole-genome sequencing of 90 Han Chinese genomes
Next-generation sequencing provides a high-resolution insight into human genetic information. However, the focus of previous studies has primarily been on low-coverage data due to the high cost of sequencing. Although the 1000 Genomes Project and the Haplotype Reference Consortium have both provided powerful reference panels for imputation, low-frequency and novel variants remain difficult to d...
متن کاملApproximate Bayesian Computations Done Exactly: Towards a Thousand Human Genomes
Currently, 1000 whole human genomes are being sequenced. It is becoming exceedingly difficult to extract critical information from such extensive population-level genomic data reliably to solve pressing biomedical problems. Several approximate methods are being used without sound statistical justification to extract information from such complex data. This project aims to develop novel theoreti...
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ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 2000
ISSN: 1087-0156,1546-1696
DOI: 10.1038/72515